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MSA-C shows grayish discoloration of thecerebellum, middle cerebellar peduncle, and the pons.There is Purkinje cell loss and proliferation of Bergmannglia, especially in the vermis. Periprosthetic joint infection following Staphylococcusaureus bacteremia. Number of patients to be treatedto prevent one death was 61.6 and 16.2 deaths were preventedin each 1,000 patients treated.60 Predictors of a poor outcomeinclude clinical evidence of RV failure, rapid progression ofdisease and advanced functional class, poor exercise capacityas measured by 6-MWD or cardiopulmonary exercise test,elevated brain natriuretic peptide, RV dysfunction or pericardialeffusion by echocardiogram and high RA pressure, high PVR,and low cardiac index by right heart catheterization (Table 3).Information from 2 large present-day registries of patients withPAH gives us the opportunity to better understand the prognosisof PAH, its determinants, and outcomes in the current treatmentera

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